Evaluación del efecto de Panax ginseng combinado con un sellador interno de pezones en la terapia selectiva para vaca seca
DOI:
https://doi.org/10.14409/favet.2025.1.e0049Palavras-chave:
Panax ginseng, sellador interno de pezones, infecciones intramamarias, Staphylococcus no aureus, terapia selectiva de secadoResumo
Se evaluó el efecto de Panax ginseng (Pg) y un sellador interno de pezones en una terapia selectiva para prevenir infecciones intramamarias (IIM) y curar IIM por Staphylococcus no aureus (SNA) al secado. La unidad experimental fue el cuarto mamario (n=140), divididos en: Grupo 1 (G1): cuartos libres de IIM, y Grupo 2 (G2): cuartos positivos a SNA. A los mismos se los dividió en dos subgrupos y se aplicó al secado Pg + sellador (G1Pg+S y G2Pg+S) o solo sellador (G1S y G2S). Se tomaron muestras de leche al posparto de todos los cuartos y las mismas fueron examinadas microbiológicamente. No se encontraron asociaciones estadísticas entre el secado y el posparto independientemente del tratamiento recibido (P=0,442). Del análisis de nuevas IIM al posparto se obtuvieron resultados similares para ambos grupos (P=0,397), obteniéndose valores de 25,8 y 19 % de cuartos con nuevas IIM para los G1Pg+S y G1 S, respectivamente. Del análisis sobre nuevas IIM por SNA se obtuvo un 75% de cura en los cuartos del G2Pg+S y G2S (P=0,999). El efecto del tratamiento de Pg+S para eliminar IIM por SNA al secado fue similar a la aplicación de sellador solo.
Referências
Abrahmsén M, Ylva P, Benon MK, Renée B. 2014. Prevalence of subclinical mastitis in dairy farms in urban and peri-urban areas of Kampala, Uganda. Trop. Anim. Health Prod. 46:99-105. DOI: 10.1007/s11250-013-0455-7.
Baravalle C, Dallard BE, Ortega HH, Neder VE, Canavesio VR, Calvinho LF. 2010. Effect of Panax ginseng on cytokine expression in bovine mammary glands at drying off. Vet. Immunol. Immunop. 138:224-230. DOI: 10.1016/j.vetimm.2010.07.019.
Baravalle C, Dallard BE, Cadoche MC, Pereyra EAL, Neder VE, Ortega HH, Calvinho LF. 2011. Proinflammatory cytokines and CD14 expression in mammary tissue of cows following intramammary inoculation of Panax ginseng at drying off. Vet. Immunol. Immunop. 144:52-60. DOI: 10.1016/j.vetimm.2011.07.003
Barkema HW, Schukken YH, Zadoks RN. 2006. Invited Review: The role of cow, pathogen, and treatment regimen in the therapeutic success of bovine Staphylococcus aureus mastitis. J. Dairy Sci. 89:1877-95. DOI: 10.3168/jds.S0022-0302(06)72256-1.
Beccaria C, Baravalle C, Silvestrini P, Renna MS, Molineri AI, Signorini ML, Neder VE, Archilla GAS, Calvinho LF, Dallard BE. 2021. Efficacy of Panax ginseng extract combined with cephalexin as a dry cow therapy. J Dairy Res. 88:64-68. DOI: 10.1017/S0022029921000017.
Bennedsgaard TW, Klaas IC, Vaarst M. 2010. Reducing use of antimicrobials experiences from an intervention study in organic dairy herds in Denmark. Livest Sci. 131:183-192. DOI: 10.1016/j.livsci.2010.03.018.
Berry EA, Hillerton JE. 2002. The effect of selective dry cow treatment on new intramammary infections. J. Dairy Sci. 85:112-121. DOI: 10.3168/jds.S0022-0302(02)74059-9.
Biggs A, Barrett D, Bradley A, Green M, Reyher K, Zadoks R. 2016. Routine antibiotic dry cow therapy. Where next?. Vet. Rec. 178:174. DOI: 10.1136/vr.i338.
Bradley AJ, Green MJ. 2004. The importance of the nonlactating period in the epidemiology of intramammary infection and strategies for prevention. Vet. Clin. North Am. Food Anim. Pract. 20:547-568. DOI: 10.1016/j.cvfa.2004.06.010.
Bradley AJ, Breen JE, Payne B, Williams P, Green MJ. 2010. The use of a cephalonium containing dry cow therapy and an internal teat sealant, both alone and in combination. J. Dairy Sci. 93:1566-1577. DOI:10 .3168/ jds .2009 -2725.
Bradley AJ, Breen JE, Payne B, Green MJ. 2011. A comparison of broad-spectrum and narrow-spectrum dry cow therapy used alone and in combination with a teat sealant. J. Dairy Sci. 94:692-704. DOI:10 .3168/ jds .2010 -3192.
Cameron M, McKenna SL, MacDonald KA, Dohoo IR, Roy JP, Keefe GP. 2014. Evaluation of selective dry cow treatment following on-farm culture: Risk of postcalving intramammary infection and clinical mastitis in the subsequent lactation. J. Dairy Sci. 97:270-284. DOI: 10.3168/jds.2014-8876.
Cobirka M, Tancin V, Slama P. 2020. Epidemiology and classification of mastitis. Animals. 10, 2212. DOI: 10.3390/ani10122212.
Crespi E, Pereyra AM, Puigdevall T, Rumi MV, Testorelli MF, Caggiano N, Gulone L, Mollerach M, Gentilini ER, Srednik ME. 2022. Antimicrobial resistance studies in staphylococci and streptococci isolated from cows with mastitis in Argentina. J. Vet Sci. 23:e12. DOI: 10.4142/jvs.21062.
Derakhshani H, Plaizier JC, De Buck J, Barkema HW, Khafipour E. 2018. Composition of the teat canal and intramammary microbiota of dairy cows subjected to antimicrobial dry cow therapy and internal teat sealant. J. Dairy Sci. 101:10191-10205. DOI: 10.3168/jds.2018-14858.
Dodd FH, Westgarth DR, Neave FK, Kingwill RG. 1969. Mastitis–The strategy of control. J. Dairy Sci. 52:689-695. DOI: 10.3168/jds.S0022-0302(69)86631-2.
Dohoo IR, Leslie KE. 1991. Evaluation of changes in somatic cell counts as indicators of new intramammary infections. Prev. Vet. Med. 10:225-237. 10:225-237. DOI: 10.1016/0167-5877(91)90006-N
Filippone Pavesi L, Pollera C, Sala G, Cremonesi P, Monistero V, Biscarini F, Bronzo V. 2023. Effect of the selective dry cow therapy on udder health and milk microbiota. Antibiotics. 12, 1259. DOI: 10.3390/antibiotics12081259
Golder HM, Hodge A, Lean IJ. 2016. Effects of antibiotic dry-cow therapy and internal teat sealant on milk somatic cell counts and clinical and subclinical mastitis in early lactation. J. Dairy Sci. 99:7370–7380. DOI: 10 .3168/ jds .2016 -11114.
Halasa T, Nielen M, van Werven T, Hogeveen H. 2010. A simulation model to calculate costs and benefits of dry period interventions in dairy cattle. Livest. Sci. 129:80-87. DOI: 10.1016/j.livsci.2010.01.009.
Hommels NM, Ferreira FC, van den Borne BH, Hogeveen H. 2021. Antibiotic use and potential economic impact of implementing selective dry cow therapy in large US dairies. J. Dairy Sci, 104(8),8931-8946. DOI: 10.3168/jds.2020-20016
Hu S, Concha C, Johannisson A, Meglia G, Waller KP. 2001. Effect of subcutaneous injection of Ginseng on cows with subclinical Staphylococcus aureus mastitis. J. Vet. Med. 48:519-528. DOI: 10.1046/j.1439-0450.2001.00470.x
Kabera F, Roy JP, Afifi M, Godden S, Stryhn H, Sanchez J, Dufour S. 2021. Comparing blanket vs. selective dry cow treatment approaches for elimination and prevention of intramammary infections during the dry period: A systematic review and metaanalysis. Front. Vet. Sci. 8:688450. DOI: 10.3389/ fvets .2021 .688450.
Kabera F, Roy JP, Keefe G, Dufour S. 2021b. Bayesian estimation of diagnostic accuracy of somatic cell counts history and on-farm milk culture using Petrifilm to identify quarters or cows that should be treated with antimicrobials in selective treatment protocols at dry off. Prev. Vet. Med. 195:105452. DOI: 10 .1016/ j.prevetmed .2021 .105452.
Kateete DP, Kabugo U, Baluku H, Nyakarahuka L, Kyobe S, Okee M, Najjuka FC, Joloba ML. 2013. Prevalence and antimicrobial susceptibility patterns of bacteria from milkmen and cows with clinical mastitis in and around kampala, Uganda. Plos one. 8:1-12. DOI: 10.1371/journal.pone.0063413.
Krömker V, Leimbach S. 2017. Mastitis treatment-reduction in antibiotic usage in dairy cows. Reprod. Domest. Anim. 52:21-29. DOI: 10.1111/rda.13032.
McCubbin KD, de Jong E, Lam TJGM, Kelton DF, Middleton JR, McDougall S, de Vliegher S, Godden S, Rajala PJ Schultz, Rowe S, Speksnijder DC, Kastelic JP, Barkema HW. 2022. Invited review: Selective use of antimicrobials in dairy cattle at dry-off. J. Dairy Sci. 105:7161-7189. DOI: 10.3168/jds.2021-21455.
McDougall S, Williamson J, Gohary K, Lacy-Hulbert J. 2021. Detecting intramammary infection at the end of lactation in dairy cows. J. Dairy Sci. 104(9),10232-10249. DOI: 10.3168/jds.2020-20036
Mullen KAE, Sparks LG, Lyman RL, Washburn SP, Anderson KL. 2013. Comparisons of milk quality on North Carolina organic and conventional dairies. J. Dairy Sci. 96:6753-6762. DOI: 10.3168/jds.2012-6519.
Naranjo-Lucena A, Slowey RJ. 2023. Invited review: Antimicrobial resistance in bovine mastitis pathogens: A review of genetic determinants and prevalence of resistance in European countries. Dairy Sci. 106:1-23. DOI: 10.3168/jds.2022-22267.
Newton HT, Green MJ, Benchaoui H, Cracknell V, Rowan T, Bradley AJ. 2008. Comparison of the efficacy of cloxacillin alone and cloxacillin combined with an internal teat sealant for dry-cow therapy. Vet. Rec. 162:678-683. DOI: 10.1136/vr.162.21.678.
Oliver SP, Lewis MJ, Gillespie BE, Dowlen HH, Jaenicke EC, Roberts RK. 2003. Prepartum antibiotic treatment of heifers: milk production, milk quality and economic benefit. J Dairy Sci. 86:1187–1193. DOI: 10.3168/jds.S0022-0302(03)73702-3
Oliver SP, Gonzalez RN, Hogan JS, Jayarao BM, Owens WE. 2004. Microbiological procedures for the diagnosis of bovine udder infection and determination of milk quality. Verona WI, USA: National Mastitis Council.
Rowe SM, Godden SM, Nydam DV, Gorden PJ, Lago A, Vasquez AK, Royster E, Timmerman J, Thomas MJ. 2020. Randomized controlled trial investigating the effect of 2 selective dry-cow therapy protocols on udder health and performance in the subsequent lactation. J. Dairy Sci. 103:6493-6503. DOI: 10 .3168/ jds .2019 -17961.
Rowe SM, Nydam DV, Godden SM, Gorden PJ, Lago A, Vasquez AK, Lynch RA. 2021. Partial budget analysis of culture-and algorithm-guided selective dry cow therapy. J. Dairy Sci. 104:5652-5664. DOI: 10.3168/jds.2020-19366.
Sanford CJ, Greg PK, Ian RD, Ken EL, Randy TD, Luc DC, Herman WB. 2006. Efficacy of using an internal teat sealer to prevent new intramammary infections in nonlactating dairy cattle. JAVMA 228:1565-1573. DOI: 10.2460/javma.228.10.1565.
Scherpenzeel CGM, den Uijl IEM, van Schaik G, Riekerink O, Hogeveen H, Lam TJGM. 2016. Effect of different scenarios for selective dry-cow therapy on udder health, antimicrobial usage, and economics. J. Dairy Sci. 99:3753-3764. DOI: 10.3168/jds.2015-9963.
Silvestrini P, Beccaria C, Pereyra EAL, Renna MS, Ortega HH, Calvinho LF, Dallard BE, Baravalle C. 2017. Intramammary inoculation of Panax ginseng plays an immunoprotective role in Staphylococcus aureus infection in a murine model. Res Vet Sci. 115:211–220. DOI: 10.1016/j.rvsc.2017.05.010
Sorensen JT, Enevoldsen C. 1991. Effect of dry period length on milk production in subsequent lactation. J. Dairy Sci. 74:1277-1283. DOI: 10.3168/jds.S0022-0302(91)78283-0.
Sun HX, Yong Xie, Yi-Ping Ye. 2009. Advances in saponin based adjuvants. Vaccine 27:1787-1796. DOI: 10.1016/j.vaccine.2009.01.091
Sun J, Hu S, Song X. 2007. Adjuvant effects of protopanaxadiol and protopanaxatriol saponins from ginseng roots on the immune responses to ovalbumin in mice. Vaccine. 25:1114-1120. DOI: 10.1016/j.vaccine.2006.09.054.
Taponen S, Koort J, Björkroth J, Saloniemi H, Pyörälä S. 2007. Bovine intramammary infections caused by coagulase-negative staphylococci may persist throughout lactation according to amplified fragment length polymorphism-based analysis. J. Dairy Sci. 90:3301-3307. DOI: 10.3168/jds.2006-860.
Weber J, Borchardt S, Seidel J, Schreiter R, Wehrle F, Donat K, Freick M. 2021. Effects of selective dry cow treatment on intramammary infection risk after calving, cure risk during the dry period, and antibiotic use at drying-off: a systematic review and meta-analysis of current literature (2000–2021). Animals (Basel).11:3403. DOI: 10.3390/ani11123403.
Winder CB, Sargeant JM, Kelton DF, Leblanc SJ, Duffield TF, Glanville J, Wood H, Churchill KJ, Dunn J, Bergevin MD, Dawkins K, Meadows S, O’Connor AM. 2019b. Comparative efficacy of blanket versus selective dry-cow therapy: A systematic review and pairwise meta-analysis. Anim. Health Res. Rev. 20:217–228. DOI: 10.1017/S1466252319000306.
Zecconi A, dell’Orco F, Rizzi N, Vairani D, Cipolla M, Pozzi P, Zanini L. 2020. Cross-sectional study on the prevalence of contagious pathogens in bulk tank milk and their effects on somatic cell counts and milk yield. Italian J. Animal Sci. 19:66-74. DOI: 10.1080/1828051X.
Downloads
Publicado
Edição
Seção
Licença
Direitos autorais (c) 2025 Camila Beccaria, Ana Molineri, Verónica Neder, Guillermo Suárez Archilla , Valerina Simonutti, Paula Silvestrini, María Sol Renna, Luis Fernando Calvinho, Bibiana Elizabet Dallard, Celina Baravalle
Este trabalho está licenciado sob uma licença Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
FAVE Sección Ciencias Veterinarias ratifica el modelo Acceso Abierto en el que los contenidos de las publicaciones científicas se encuentran disponibles a texto completo libre y gratuito en Internet, sin embargos temporales, y cuyos costos de producción editorial no son transferidos a los autores. Esta política propone quebrar las barreras económicas que generan inequidades tanto en el acceso a la información, como en la publicación de resultados de investigaciones.
Los artículos de la revista son publicados en http://bibliotecavirtual.unl.edu.ar/publicaciones/index.php/FAVEveterinaria/issue/current/, en acceso abierto bajo licencia Creative CommonsAtribución-NoComercial-Compartir Igual 4.0 Internacional.
